NEW YORK — Helen Mirren is set to play the title role in “Killing Mrs. Tingle,” the horror comedy written and to be di-rected by “Scream” scribe Kevin Williamson for Dimension Films. Williamson is now putting together the group of students intent on bumping off their most detested teacher, and he’s cast as the ringleader Katie Holmes, star of his WB series “Dawson’s Creek.”The film, which will begin shooting in April, marks Williamson’s directorial debut and will be produced by Richard Gladstein. Dimension prexy Cary Granat put the deal together with Cary Meadow, veep for legal and biz affairs. For Mirren, the role marks a return to Miramax, which distributed the Peter Greenaway-directed “The Cook, The Thief, His Wife and Her Lover,” in which Mirren starred as the wife of an abusive spouse. More recently, Mirren has won two Emmys for her role as Detective Chief Inspector Jane Tennison in the BBC miniseries “Prime Suspect.” Prior to “Dawson’s Creek,” Holmes appeared in Ang Lee’s “The Ice Storm.” Mirren is repped by ICM’s Toni Howard and Brian Mann, with Holmes repped by CAA’s Brandt Joel and attorney Patti Felker.