Parker Posey, the hardest working girl in indie show business, is in final talks to star in the screwball com-edy “The Misadventures of Margaret.”

Posey, who appeared in three pics that unspooled at the Sundance Film Fest this year — “The House of Yes,” “Clockwatchers” and “SubUrbia” —is expected to take the role to which Janeane Garofalo formerly had been attached.

Pic marks the feature film debut of Brit documentary helmer Brian Skeet, who adapted the story from Cathleen Schine’s novel “Rameau’s Niece.” Skeet will produce “Misadventures” with his partner, Ian Benson.

“The Misadventures of Margaret” is a modern Candida tale about a 28-year-old academic who achieves fame when she pens a tawdry novel. When she begins work on her new book — an adaptation of an 18th-century erotic diary — she begins to question her life and her 10-year marriage to a staid Columbia U. lecturer.

The film, reported to have a $5 million below-the-line budget, will be distributed internationally by Granada. Do-mestic distribution rights have not been set. Pic has a tentative start date of June 1.

The actress, who first segued to film (“The Coneheads”) after spending a year on the daytime soap “As the World Turns,” has appeared in more than 20 films, including “Party Girl” and “Dazed and Confused.”

Posey has been dubbed the queen of the indies for her numerous roles in festival-driven films. In fact, she won a special prize for acting from the dramatic jury at Sundance this year. She’s now on screen in “Waiting for Guff-man” and “The Daytrippers.”

Parker also appears in the upcoming pics “Edwards and Hunt: The First American Road Trip,” “Dumb in Love” and “Dinner at Fred’s.”

Skeet first made a name for himself in the U.K. for a BBC documentary about L. Frank Baum and Oz. The film-maker also recently finished an adaptation of Jane Stanton Hitchcock’s “The Witch’s Hammer.”

Posey is repped by William Morris agents Michael Gruber and Frank Frattaroli in New York.

She’s managed by Banner Entertainment.

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