MADRID — Polygram’s high-profile fall release “The Game,” directed by David Fincher and starring Michael Douglas, will make its Euro premiere when it closes the 45th San Sebastian Film Festival (Sept. 18-27).

The fest’s opening film will be “My Best Friend’s Wedding,” the first U.S. pic from Australian director P.J. Hogan.

According to sources, Douglas will attend the San Sebastian Fest. The selection of the festival for the Euro preem indicates a growing trend by savvy distributors to boost the Spanish box office of a pic by having it in a key slot at the festival.

Susan Sarandon attended the fest’s 1995 edition, in part to promote Polygram’s “Dead Man Walking,” which in Spain eventually hit its highest B.O. result of any territory in Europe.

Preeming in the U.S. next month, “The Game” marks Polygram Filmed Entertainment’s first Stateside release under its new, stand-alone distrib operation. The film, Fincher’s follow-up to “Seven,” stars Douglas and Sean Penn in what is described as a psychological thriller with a kinky, sexy bent.

Follow @Variety on Twitter for breaking news, reviews and more