Meg Ryan is stepping up activities under her Fandango banner at 20th Century Fox, with plans to star in “Best Friends,” a dark comedy produced by Anne Harrison.The script, written by Lenore Kletter, is described as a “War of the Roses”-type comedy about an escalating confrontation between two pairs of best friends. No director has been attached. Also in development at Fox is aremake of “Two for the Road,” produced by Cathleen Summers, in which Ryan is planning to star. Audrey Hepburn and Albert Finney starred in the 1967 original. The actress has amassed about half-dozen projects under her nonexclusive deal , with one — a dark romantic comedy “Jump!”– jumping over to TriStar. It was penned by Mark Andrus. Other films in earlier stages of development include “Heir Not Apparent,” Mike Love and Martin Salinas’ mystery involving Howard Hughes, and “Arturo,” a Ron Bass romance that will star Ryan and Andy Garcia. In upcoming months, Ryan will also step behind the camera to direct a Showtime special, “Emergency,” based on a short story by Denis Johnson. It is about emergency-room orderlies in the 1970s who are on mind-altering drugs. As activities step up at Fandango, Ryan and Kathryn Galan, who was recently brought on as a producing partner, have hired Wayne Pepper as a development executive. Pepper was a story analyst at Creative Artists Agency and worked at Filmstar Inc. prior to that. They have hired Daniel Blatt as office administrator. He most recently worked in the story department at Capella Films.